中文 Contact
  • About CAAS
    Introduction
    Mission & Vision
    Leadership
    CAAS In Numbers
    Organization
  • Newsroom
    Focus News
    Latest News
    Research Updates
    Bulletins
  • Research & Innovation
    Major Achievements
    Research Areas
    Facilities
    ASTIP
    Innovation Teams
  • International Cooperation
    Partners
    Platforms
    Initiatives
  • Join Us
    Talent Recruitment
    Career Opportunities
    Postgraduate Education
  • Media
    Annual Report
    Video
    CAAS in Media
    Journal
Back CAAS 中文 Contact
  • About CAAS
    Introduction
    Mission & Vision
    Leadership
    CAAS In Numbers
    Organization
  • Newsroom
    Focus News
    Latest News
    Research Updates
    Bulletins
  • Research & Innovation
    Major Achievements
    Research Areas
    Facilities
    ASTIP
    Innovation Teams
  • International Cooperation
    Partners
    Platforms
    Initiatives
  • Join Us
    Talent Recruitment
    Career Opportunities
    Postgraduate Education
  • Media
    Annual Report
    Video
    CAAS in Media
    Journal

Newsroom

Home- Newsroom- Research Updates
Home- Newsroom- Research Updates
分享到

Innovative Enzyme-Resistant Nano-Antimicrobial Peptides Combat Drug-Resistant Bacterial Infections

小 中 大
Source : Institute of Feed Research

Recently, the Active Peptide and Feed Innovation Research Team from the Institute of Feed Research, Chinese Academy of Agricultural Sciences developed a bacteria-responsive self-assembling antimicrobial peptide based on precise module design strategies. The relevant research findings have been published in the Journal of Nanobiotechnology .

The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Antimicrobial peptides (AMPs) have garnered attention due to their high antimicrobial activity and low resistance. However, their susceptibility to enzymatic degradation in vivo is a bottleneck in their clinical application.

In this study, based on the precise module design strategies of self-assembled peptides and antibacterial structure function relationships, a bacterial-responsive self-assembly platform consisting of hydrophobic, hydrogen-bonding and antimicrobial modules were constructed and screened potent antimicrobial, highly stable and low-toxicity in situ self-assembled AMPs. The screened AMP self-assembled into nanoparticles in vitro and initiated nanoparticle-to-nanofiber conversion under the action of bacterial cell wall LTA or LPS nucleation sites, thereby achieving bacterial capture and further disrupting the cell membrane lipid bilayer arrangement of the bacterial cell membrane and causing bacterial death. In vivo mouse mastitis infection model further confirmed the therapeutic potential and promising biosafety of the self-assembled peptide, which can effectively alleviate mastitis caused by MDR Escherichia coli  and Staphylococcus aureus , and eliminate pathogenic bacteria. Hence, the self-assembled AMPs have emerged as a viable and potent therapeutic intervention, exhibiting notable efficacy in both systemic and localized therapeutic strategies. The study provides new insights into the research of AMPs stabilization techniques and offers solutions for inhibiting multiple drug-resistant bacterial infections.

The research was supported by the National Key Research and Development Plan, the National Natural Science Foundation of China, and The Innovation Program of Agricultural Science and Technology (ASTIP) in Chinese Academy of Agricultural Sciences (CAAS) and its key projects.

Original link: https://doi.org/10.1186/s12951-024-02896-5

Source: Na Yang, yangna@caas.cn

7.示意图.jpg

Self-assembly diagram of nano-antimicrobial peptides

Latest News
  • Nov 07, 2024
    The Policy and Technology Exchange Meeting of Deepening Environmental Cooperation on Dust and Sand Storm Control in Northeast Asia for Green and Sustainable Development co-organized by Institute of Grassland Research, CAAS successfully held in Hohhot
  • Nov 07, 2024
    IAED-CAAS delegation visits four Central-Asian countries for scientific cooperation
  • Nov 06, 2024
    Experts from ICS Participated in the 3rd IWC
  • Oct 24, 2024
    Prof. Luxiang Liu Renewed His Term as the Chairman of the Mutation Breeding Network (MBN)
  • Oct 23, 2024
    IPPCAAS Wins the 2024 FAO Achievement Award
  • About CAAS
    Introduction
    Mission & Vision
    Leadership
    CAAS In Numbers
    Organization
  • Newsroom
    Focus News
    Latest News
    Research Updates
    Bulletins
  • Research & Innovation
    Major Achievements
    Research Areas
    Facilities
    ASTIP
    Innovation Teams
  • International Cooperation
    Partners
    Platforms
    Initiatives
  • Join Us
    Talent Recruitment
    Career Opportunities
    Postgraduate Education
  • Media
    Annual Report
    Video
    CAAS in Media
    Journal

Links

Ministry of Agriculture and Rural Affairs of the People's Republic of China
Giving to CAAS

CAAS

Copyright © 2023 Chinese Academy of Agricultural Sciences京ICP备10039560号-5 京公网安备11940846021-00001号

No.12 Zhongguancun South Street, Haidian District, Beijing, P.R.China

www.caas.cn/en/

diccaas@caas.cn

Top