Asian corn borer (ACB), Ostrinia furnacalis (Guenée), which is the major insect pest of maize in China and countries of East and Southeast Asia, the Pacific and Australasia, can develop strong resistance to the transgenic Bt maize expressing Cry1Ab toxin, the most widely commercialized Bt maize worldwide. Understanding the molecular mechanism of resistance to Cry1Ab in ACB is essential for effective managing and/or delaying the evolution of resistance. Recently, researchers at the State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection of CAAS have published a research paper about the transcriptome differences between Cry1Ab resistance and susceptible strains of ACB (ACB-BtS and ACB-AbR), which provides a valuable genomic resource for further understanding the molecular basis of Bt resistance mechanisms in ACB.