The resistance evolution of vegetable pests in the field in China is becoming more and more serious, but the resistance mechanism is still unclear. This study has discovered the pivotal signal pathways for orchestrating the resistance of the important vegetable pests including the whitefly (Bemisia tabaci) to the chemical insecticide imidacloprid and the diamondback moth (Plutella xylostella) to the Bt bioinsecticide, and it initially developed a precise field resistance monitoring and early warning technology oriented by the key genes of these signaling pathways. These findings have important theoretical and practical significance for the monitoring, early warning and field management of the resistance evolution of major agricultural pests and for the development of new, green and efcient insecticides.

The molecular mechanism of MAPK-directed activation of the whitefly transcription factor CREB leads to P450- mediated imidacloprid resistance